Non-invasive preclinical imaging methods are critical for development of imaging agents and targeted therapeutics. Pharmacokinetics is the study of what the body does to a drug with respect to biodistribution and clearance. Traditionally-used radiolabeled probes have limitations such as cost, access, and safety. Near-infrared (NIR) fluorescence imaging offers a powerful alternative to radiolabeled probes for pharmacokinetics and biodistribution studies. NIR fluorescent optical imaging agents can be used to image the whole animal over time. And, more than one agent can be tracked in the same animal if each agent is labeled with a spectrally-distinct fluorophore.
In this webinar, Dr Amy Geschwender examines several case studies from the literature, and discusses:
- Why NIR fluorescent probes are widely used for in vivo imaging
- How fluorescence imaging of excised tissues and tissue sections is used to examine biodistribution in more detail
- How to measure serum half-life and % injected dose per gram with NIR fluorescent probes
This webinar features data from the Pearl® Small Animal Imaging System, which was recently honored by Frost & Sullivan, in addition to advancements in NIR technology. Click here to learn more about this award.