LI-COR's Life Science Network

Mitosciences^®

MitoSciences is a leading developer of mitochondrial antibodies and mitochondrial assays that are used for studying metabolism and apoptosis. These areas of study are essential for finding answers to cancer, neurodegeneration, aging, diabetes and obesity. MitoSciences uses the LI-COR Odyssey^® Infrared Imaging System, IRDye^® Reagents and IRDye^® Secondary Antibodies in their product development to ensure the highest quality product for their customers.

Please visit http://www.mitosciences.com for more information on these products.

Click here for more information on LI-COR Biosciences' cancer research tools.

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R&D Systems^®

R&D Systems now offers Cell-Based Infrared ELISA kits that utilize LI-COR^® IRDye^® 800CW-conjugated and IRDye 680LT-conjugated secondary antibodies that are compatible with the LI-COR Odyssey^® Infrared Imaging System. These ELISA kits are used for measuring protein phosphorylation or total protein levels in whole, fixed cells, eliminating the need for lysate preparation.

The R&D Systems Proteome Profiler Antibody Arrays allow for the measurement of multiple proteins in a single sample. The arrays were originally developed for chemiluminescent detection, but select arrays can be adapted for use with near-infrared (NIR) fluorescence detection using the LI-COR Odyssey^® Infrared Imaging System. To make this adaption an IRDye^® 800CW labeled Streptavidin is used in place of the HRP-conjugated Streptavidin found in the kit. The resulting arrays are then scanned using the Odyssey Infrared Imaging System.

The R&D Systems Cell-Based Infrared ELISA kits include:

• Akt - Phospho-Akt (S473) Pan Specific Cell-Based Infrared ELISA Kit
• Caspase-3 - Human Cleaved Caspase-3 (Asp175) Cell-Based Infrared ELISA Kit
• EGF R/ErbB1 - Human Phospho-EGF R (Y1068) Cell-Based Infrared ELISA Kit
• ERK1/ERK2 - Phospho-ERK1/ERK2 Cell-Based Infrared ELISA Kit

The R&D Systems Arrays that can be adapted for use with the LI-COR detection system:

• Proteome Profiler™ 96 Infrared Antibody Array
• Human Angiogenesis Array Kit
• Human Cytokine Array Panel A
• Mouse Cytokine Array Panel A
• Rat Cytokine Array Panel A

Please visit http://www.rndsystems.com for more information on these products.

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BioTek^® Instruments, Inc.

As a leader in aiding the advancement of life science research, BioTek Instruments, Inc. has helped to integrate the BioStack™ Microplate Stacker with the LI-COR Odyssey^® Sa Imaging System to allow for the automation of plate reading. The BioStack offers increased throughput for a variety of applications in genomics, proteomics, drug discovery and clinical diagnostics.

Please visit http://www.biotek.com for more information on this product.

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BellBrook Labs

BellBrook Labs is a leading provider of screening tools to the pharmaceutical industry. Assays like the Transcreener^® HTS Platform are used to accelerate the discovery of more effective disease therapies. Several Transcreener^® FI Assays utilize the LI-COR IRDye^® QC-1 quencher conjugate to provide increased assay sensitivity.

Please visit http://www.bellbrooklabs.com for more information on these products.

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Metabion, International AG

Metabion, International AG is a leading international manufacturer of custom oligonucleotides. Its oligonucleotides are made to order with specified sequences that are used in a variety of applications, from PCR and sequencing, to probes for gene detection. Metabion uses LI-COR IRDye^® technology as one option that customers may select when designing custom fluorescent dye-labeled oligonucleotides.

Please visit http://www.metabion.com for more information on these products.

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Integrated DNA Technologies

IDT is the leading manufacturer of custom oligonucleotides in the United States. Its oligonucleotides are used in diagnostic testing for diseases like cancer, hepatitis and AIDS. IDT uses LI-COR IRDye^® technology for customer-requested custom oligonucleotides that are on the cutting edge of drug discovery, disease treatment, and agricultural production.

Please visit http://www.idtdna.com for more information on these products.

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Molecular Targeting Technologies, Inc.

Molecular Targeting Technologies, Inc. (MTTI) is a biotechnology company primarily focused on the development of small molecules for the molecular imaging of diseases such as cancer and bacterial infections.

LI-COR Biosciences and MTTI have worked together to offer PSVue^® 794, a near-infrared fluorescent prove for researchers who have the need to detect bacteria, apoptotic and necrotic cells, or other anionic membranes for in vivo or in vitro use. PSVue 794 binds to a variety of cell types that have negatively-charged phospholipids exposed on their membranes, including necrotic cells, Gram-negative and Gram-positive bacteria, activated cells, tumor vascular endothelial cells, viruses, etc. PSVue 794 is available in a range of detection wavelengths, from long-UV to near-infrared and is suitable for high-throughput screening assays.

The fluorescent CellVue^® cell labeling kits from MTTI are versatile, provide stable labeling with minimal transfer from cell to cell, and provide rapid, uniform membrane labeling. Additionally, MTTI CellVue kits are optimized for multiple wavelengths, including near-infrared fluorescence. The excitation and emission properties of CellVue Burgundy and CellVue NIR815 dyes are compatible with a range of commercially-available near-infrared plate readers, flow cytometers, in vitro and in vivo fluorescent imaging systems, and confocal microscopes.

Because of their properties, PSVue 794 and CellVue dyes, when used with a LI-COR Odyssey^® CLx Infrared Imaging System or Pearl^® Impulse, provide the researcher with valuable tools for a multitude of in vivo and in vitro cell studies using fluorescent membrane labels.

Please visit http://www.mtarget.com/mtti/home.html for more information on these products.

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