October 5, 2010, Lincoln, Nebraska: IRDye® 800CW HA Optical Probe for in vivo imaging is the latest addition to the BrightSite™ Optical Agent family from LI-COR Biosciences. Hyaluronan (hyaluronic acid; HA) is an extracellular matrix glycosaminoglycan formed from disaccharide units containing N-acetylglucosamine and glucuronic acid.
"This agent is useful for researchers looking to specifically target the lymphatic system, or tumor cells that over express CD44 receptors," says Jeff Harford, LI-COR product manager.
Hyaluronan interacts with several cell surface receptors, namely CD44, RHAMM (receptor for hyaluronan mediated motility; CD168), LYVE-1 (lymphatic vessel endothelial HA receptor-1), HARE (hyaluronan receptor for endocytosis), layilin, and Toll-4. It binds to proteoglycans in cartilage and other tissues and fills an important structural role in the organization of the extra-cellular matrix. The agent is catabolized by receptor-mediated endocytosis and lysosomal degradation after transport via the lymph-to-lymph nodes.
LI-COR offers a complete line of BrightSite Optical Agents for use on its Pearl® Impulse small animal imaging system and other systems that use near-infrared detection methods. Additional BrightSite Optical Agents include: 2-DG Optical Probe, EGF Optical Probe, RGD Optical Probe, BoneTag™ Optical Probe, and PEG Contrast Agent.