PEARL IMAGER
PEARL IMAGER
Sensitive Infrared Detection for In Vivo Imaging
The Pearl® Imager allows researchers to use native cells and cell lines for their in vivo imaging work. Laser excitation and optimized near-infrared fluorescence detection results in unparalleled sensitivity, as well as deep target imaging. Simple one-button operation and 30-second image acquisition make the Pearl Imager the preferred system in any core imaging lab.
The ready availability of leading targeting agents means your research can proceed immediately without have to wait for targeting agent development.
Laser based excitation and near-infrared optimization result in exceptional sensitivity with deeper tissue penetration and earlier target detection.
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One button operation and 30 second acquisition of 3 channels (700, 800 and white light) enables rapid screening of animals and simultaneous screening of different targets.
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Using IRDye® targeting agent solutions for fast research startup.
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With HEPA filtered imaging beds for immunocompromised animals, docking stations and anesthesia systems.
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A complete Solution for targeting agent development and in vivo imaging.
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Publications
Hyaluronidase expression induces prostate tumor metastasis in an orthotopic mouse model
RGD – Human serum albumin conjugates as efficient tumor Targeting Probes
Webinars
Instrumentation and Imaging Considerations
- Dr. Eva M. Sevick-Muraca
Seminar on the value of NIR imaging and how it compares to other imaging technologies.
In Vivo Tracking of the BChE/IRDye® 800CW Complex in BChE Knockout Mice
- Ellen Duysen
Seminar highlighting the use of the LI-COR Pearl Imager for detection of IRDye® labeled BChE.
Dimensions: (WxDxH) cm: 41x41x64 (AND) Weight (lb/kg): ~55/25
Dynamic Range: 22 bit
Detector Type: CCD. Thermoelectrically cooled.
Acquisition Time: 10-40s
Resolution: 85 or 170 micron
Capacity: 1 animal
Normalize LUT: A single click links all selected images to the same look-up table for accurate visual comparison. (A look-up table converts fluorescent intensity values to pixel intensities.)
Channels: 3
Colors: 700 nm, 800 nm and white light
| Channel | Excitation | Emission |
|---|---|---|
| 700 nm | 685 nm | 720 nm |
| 800 nm | 785 nm | 820 nm |
| White | White | * |
Native Cell Compatibility: Yes. Does not require transfected cells or cell lines.
Means of Targeting: Near-infrared labeled targeting agents.
Custom Labeling: Via various near-infrared fluorescent dyes with NHS ester and maleimide functional groups and labeling kits.
Standard Imaging Bed: 16.8 cm W x 12 cm D (6.6” W x 4.75” D). Vertical clearance to top of drawer is 3.8 cm (1.5”).
Field of View: 11.2 cm W x 8.4 cm D (4.4” W x 3.3” D) at the surface of the imaging bed.
Imaging Bed Temperature Range: 32-42 °C.
Gas Anesthesia: Inlet and outlet ports flow anesthesia gas through a nose cone in the imaging drawer. A rotameter is included for controlling flow rate.
Size: 41 W x 41 D x 66 cm H (16” W x 16” D x 26” H). Depth with imaging drawer open is 63.5 cm (25”). Portable. Small footprint for added mobility and easy placement in any lab.
Weight: 23 kg. (50 lb).