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Dyes for Your Near-Infrared Imaging Needs
IRDye® 680RD RGD Optical Probe
IRDye 680RD RGD Optical Probe is a near-infrared labeled BrightSite™ imaging agent specifically designed to target the overexpression of integrins on tumors. Integrins are cell surface heterodimeric glycoproteins involved in cell-to-cell and cell-to-matrix interactions. The recognition motif, RGD (Arg-Gly-Asp), is a tripeptide sequence used to bind integrin receptors including αvβ3. Interest in using a labeled RGD peptide ligand for the study and/or monitoring of diseases related to the αvβ3 receptor over expression is increasing. Several groups have labeled RGD successfully with fluorescent dyes for in vitro and in vivo imaging.
Figure 1. An athymic nude mouse bearing a subcutaneous tumor, U87 (right; arrow), was imaged 24 h post intravenous injection of IRDye 680RD RGD (2 nmol). Image was captured on the Pearl® Imager; 700nm signal is presented in pseudocolor overlaid on a white light image of the mouse.
Ordering Information
Please see our new Online Catalog for the latest ordering information.Advantages of BrightSite™ Optical Agents
- High signal-to-noise ratio.
- Low NIR autofluorescence from tissues, cells, biological materials, and drug compounds.
- IRDye 680RD and 800CW absorption/emission near 700 and 800 nm, respectively, matche NIR absorption minima for bodily fluids and tissues, resulting in excellent tissue penetration.
Molar extinction coefficient characteristics of water, hemoglobin and oxygenated hemoglobin (400-1000 nm). IRDye® infrared dyes have ideal excitation/emission wavelengths for in vivo imaging.
IRDye® 680RD RGD Optical Probe is composed of the recognition motif, RGD (Arg-Gly-Asp), a tripeptide sequence used to bind integrin receptors including αvβ3. This receptor class is involved in tumor growth, tumor invasiveness, metastasis, tumor-induced angiogenesis, inflammation, osteoporosis, and rheumatoid arthritis.
Properties (in 1X PBS)
- Absorption maximum: 673 nm
- Emission maximum: 695 nm
Brochures & Data Sheets
Posters
Kovar, J.L., et al.
Integrin-specific near infrared optical imaging agent for tumor-induced angiogenesis detection in mice
Webinars
Cancer Research Webinar Series Part 5: Target Fluorescent Contrast Agents for Image-Guided Cancer Surgery
- Dr. D. Michael OliveComparison of visible and near-infrared wavelength-excitable fluorescent dyes for molecular imaging of cancer
- Dr. Eva Sevick-Muraca and Dr. Shi Ke, Baylor College of MedicineSystematic Evaluation of Targeted IRDye® Labeled Optical Imaging Agents
- Joy Kovar, Sr. ScientistCancer Research Webinar Series Part 3: In Vivo Imaging with Near-Infrared Fluorescent Optical Probes
- Dr. Amy Geschwender
Publications
For related IRDye optical probe-related publications, go to IRDye 800CW RDG Publications.
