Publications: Bone Imaging

Bone Imaging
Nude mice were injected intravenously with IRDye 680 BoneTag optical agent.

Kovar et al.1 developed calcium-chelating compounds conjugated to either IRDye 680 or IRDye 800CW NIR dyes. Use of IRDye NIR dyes extends fluorescence signal detection to the NIR region of the spectrum without affecting the compound's ability to function as a marker of the mineralization process. In addition, IRDye labeled pamidronate was successfully used for detection of arterial calcification in non-invasive optical imaging2.

1Characterization and Performance of a Near-Infrared 2-Deoxyglucose Optical Imaging Agent for Mouse Cancer Models
Joy L. Kovar*, William Volcheck, Eva Sevick-Muraca, Melanie A. Simpson, D. Michael Olive
Analytical Biochemistry, Vol. 384 (2009) 254-262.

2Optical Imaging of Hydroxyapatite in the Calcified Vasculature of Transgenic Animals
Atif Zaheer, Monzur Murshed, Alec M. De Grand, Timothy G. Morgan, Gerard Karsenty, and John V. Frangioni
Arterioscler Thromb Vasc Biol, May 2006; 26: 1132 - 1136.