Publications: Tumor Imaging Prostate: PSMA

IRDye was used to label a small molecule specific for the active site of the enzyme PSMA. They described the preparative production of enzymatically active PSMA using a baculovirus expression system and an adenovirus that co-expresses PSMA and GFP. They demonstrated sensitive and specific in vitro imaging of endogenous and ectopically expressed PSMA in human cells and in vivo imaging of xenograft tumors.

High-affinity near-infrared fluorescent small-molecule contrast agents for in vivo imaging of prostate-specific membrane antigen.
V Humblet, R Lapidus, LR Williams, T Tsukamoto, C Rojas, P Majer, B Hin, S Ohnishi, AM De Grand, A Zaheer, JT Renze, A Nakayama, BS Slusher, and JV Frangioni
Mol Imaging, October 1, 2005; 4(4): 448-62..