Publications: Tumor Imaging Small Molecule

Targeted Imaging of Colonic Tumors in Smad3—/— Mice Discriminates Cancer and Inflammation.
Natasha G. Deane, H. Charles Manning, A. Coe Foutch, M. Kay Washington, Bruce A. Aronow, Darryl J. Bornhop, and Robert J. Coffey
Mol. Cancer Res., Apr 2007; 5: 341 - 349.

Deane et al. prepared NIR-conPK11195 labeled with IRDye 800CW and tested it as a targeted imaging agent for colonic tumors in Smad3-/- mice. NIR-conPK11195 was shown to be an imaging agent that could be used to screen cohorts of mice during tumor development, even on the background of accompanying or experimentally induced inflammation. They concluded the imaging strategy provides a widely applicable, rapid, and inexpensive means of detecting colonic adenomas and carcinomas in the background of benign tumors and/or inflammation.

Binding of NIR-conPK and NIR-6T to astrocytomas and microglial cells: evidence for a protein related to TSPO.
M Sexton, G Woodruff, E Cudaback, FR Kreitzer, C Xu, YH Lin, T Moller, M Bai, HC Manning, D Bornhop, and N Stella
Mol Imaging, October 1, 2005; 4(4): 448-62.