Listed below are recent publications in which authors have used protein arrays, including antibody arrays and reverse phase lysate arrays, imaged on the Odyssey® Imaging Systems for a wide range of research areas.
Search our database for relevant peer-reviewed journal citations.
Vegas, A.J., et al.
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates
Nat. Biotechnol., 2016 Mar; 34: 345–352.
Application: Quantitative analysis of cytokines in a mouse model of biomaterial-induced inflammation using a commercially available antibody array and IRDye® 800CW streptavidin.
Obenauf, A.C., et al.
Therapy-induced tumour secretomes promote resistance and tumour progression
Nature, Apr 2015; 520: 368–372.
Application: Quantitative analysis of cytokines in a mouse model of melanoma using a commercially available antibody array, IRDye® streptavidin, and Image StudioTM software.
Altara, R., et al.
Improving membrane based multiplex immunoassays for semi-quantitative detection of multiple cytokines in a single sample
BMC Biotechnol., Jul 2014; 14: 63.
Application: Quantitative analysis of chemokines and cytokines from mouse, rat, and human samples using a commercially available antibody array and IRDye® 800CW streptavidin for fluorescent detection. Comparisons made with chemiluminescent detection on film as well as colorimetric ELISA.
Beyrakhova, K.A., et al.
Structural and Functional Investigations of the Effector Protein LpiR1 from Legionella pneumophila
J. Biol. Chem., Jul 2016; 291: 15767–15777.
Shannan, B., et al.
Enhancing the evaluation of PI3K inhibitors through 3D melanoma models.
Pigment Cell Melanoma Res., May 2016; 29: 317–328.
Gaunt, E., et al.
Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection
eLife, Feb 2016; 5: e12735.
Vieira Silva, J., et al.
Profiling signaling proteins in human spermatozoa: biomarker identification for sperm quality evaluation.
Fertil. Steril., Oct 2015; 104: 845–856.e8.
Olmez, I., et al.
Dedifferentiation of patient-derived glioblastoma multiforme cell lines results in a cancer stem cell-like state with mitogen-independent growth
J. Cell. Mol. Med., Jun 2015; 19: 1262–1272.
Yun, M.H., et al.
Recurrent turnover of senescent cells during regeneration of a complex structure
eLife, May 2015; 4: e05505.
Tidball, A.M., et al.
A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease
Hum. Mol. Genet., Apr 2015; 24: 1929–1944.
Musante, L., et al.
Proteases and Protease Inhibitors of Urinary Extracellular Vesicles in Diabetic Nephropathy
J. Diabetes Res., Mar 2015; 2015: 289734.
Garczorz, W., et al.
Effects of incretin agonists on endothelial nitric oxide synthase expression and nitric oxide synthesis in human coronary artery endothelial cells exposed to TNFα and glycated albumin.
Pharmacol. Rep., Feb 2015; 67: 69–77.
Rosendahl, A.H., et al.
Conditionally immortalized human pancreatic stellate cell lines demonstrate enhanced proliferation and migration in response to IGF-I.
Exp. Cell Res., Jan 2015; 330: 300–310.
NOTE: Commercially available array for human angiogenesis detected by chemiluminescence using the Odyssey® Fc and analyzed with Image StudioTM software.
Reverse-Phase Protein Arrays (RPPAs)
Negm , O.H., et al.
Clinical utility of reverse phase protein array for molecular classification of breast cancer
Breast Cancer Res. Treat., Jan 2016; 155: 25–35.
Application: Quantitative analysis of samples extracted from formalin-fixed breast cancer tissues using IRDye® Secondary Antibodies. Comparisons made with standard immunohistochemistry.
Greco, E., corresponding author Aita, A., et al.
The novel S59P mutation in the TNFRSF1A gene identified in an adult onset TNF receptor associated periodic syndrome (TRAPS) constitutively activates NF-κB pathway
Arthritis Res. Ther., Apr 2015; 17: 93.
Application: Quantitative analysis of the NF-B signaling pathway in HEK-293 cells transfected with wild-type and mutant TNFRSF1A cDNA vectors. Signals detected with IRDye® Secondary Antibodies.
Sonntag, J., et al.
Reverse phase protein array based tumor profiling identifies a biomarker signature for risk classification of hormone receptor-positive breast cancer
Transl. Proteom., March 2014; 2: 52–59.
Application: Quantitative analysis of tumor lysates from human patients diagnosed with invasive breast carcinoma. Fast Green FCF staining and imaging used for normalization of array signals to total protein.
Aleskandarany, M.A., et al.Devika
The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts
Breast Cancer Res. Treat., Feb 2016; 156: 9–20.
Fallahi-Sichani, M., et al.
Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis
Mol. Syst. Biol., Mar 2015; 11: 0797.
Jerjees, D.A., et al.
The mammalian target of rapamycin complex 1 (mTORC1) in breast cancer: the impact of oestrogen receptor and HER2 pathways.
Breast Cancer Res. Treat., Feb 2015; 150: 91–103.