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Vascular and Lymphatic Imaging

Dorsal view of athymic male nu/nu mouse, with A431 subcutaneous tumor on the right flank.

Figure 1 Dorsal view of athymic male nu/nu mouse, with A431 subcutaneous tumor on the right flank. IV injection of IRDye 800CW PEG was administered ~1 hr prior to image capture with the Pearl Imager. Increased vasculature is seen in the tumor region.

Imaging of targeting agents in the vascular and lymphatic systems is a specialized type of biodistribution study.

Tumor vasculature commonly displays enhanced permeability and retention. The vascular endothelium in the tumor microenvironment is often discontinuous, allowing molecules to diffuse into surrounding tissue.1,2 Lymphatic drainage in these regions is also poor.3

  • These properties cause larger molecules to accumulate in tumors
  • Can be exploited for molecular imaging of cancer
Frost & Sullivan Award

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Note: IRDye® 680LT dye products should not be used for small animal in vivo imaging or
In-Cell Western™ Assays. The higher level of fluorescent intensity creates high background making it unfavorable for use in these applications. We recommend using IRDye 680RD dye products for these applications.


  • 1. Vasey, PA, et al. 1999. Clin. Cancer Res. 5: 83-94.
  • 2. Matsumura, Y and H Maeda. 1986. Cancer Res 46: 6387-6392.
  • 3. Seymour, LW. 1992. Crit. Rev. Ther. Drug Carrier Syst. 9(2): 135-187.


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