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Customize Our Technology Solutions to Your Research Needs

Are constraints in lab resources, expertise, or time keeping you from making groundbreaking discoveries? Take your project forward with innovative near-infrared fluorescence imaging solutions for any leg of the relay: from bench to translational.

Chemistry and Conjugation Services

LI-COR IRDye® Infrared Dye fluorophores are enabling quantitative detection in biosciences: from in vitro assays, in vivo imaging and therapeutic applications, to investigational Phase I and II clinical trials.

  • LI-COR has been granted dozens of cyanine-based dye patents on composition of matter and methods in the United States and worldwide
  • More than 100 publications cite IRDye infrared dye products in therapeutic and diagnostic applications

See how you can answer complex research questions with our sensitive, quantitative, photo-stable dye technology.

Taking Compounds from Structures to Yield

Get on-demand synthesis of organic compounds; starting materials, intermediates, or derivatives, from milligram to multigram amounts. LI-COR Custom Services can also help you optimize syntheses and chemical modification reactions for small molecule compounds and dyes.

You can rely on our chemists’ expertise to label biomolecules, polymers, nanoparticles, and other compounds with IRDye fluorophores for sensitive detection of your assays. If you have other fluorescent or non-fluorescent labels and quenchers in mind, we can help you conjugate and optimize those, as well.

When you need to run a purity check or an ICH stability study for your compounds, our facilities are equipped to fulfill your project needs. We can also provide a complete analytical workup for your compounds.

Ask us about:

  • Organic Synthesis
  • Biomolecule Conjugation
  • Dual Labeling and Quenching Applications
  • Reverse Phase Purification
  • FLASH Chromatography
  • High Performance Liquid Chromatography (HPLC) analysis
  • Gas Chromatography Mass Spectrometry (GC/MS)
  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • UV/Vis Spectrophotometry
  • Fourier Transform Infrared Spectroscopy (FTIR)
  • Karl Fischer Titration
  • Quantum Yield
  • ICH Stability Studies
  • Extinction Coefficient

Explore your possibilities with IRDye technology.

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Biological Assay Services

With their wide dynamic range and superior detection sensitivities, LI-COR Odyssey® Imaging Systems are setting the industry standard in quantitation of biological assays with high reproducibility.

  • LI-COR has been granted more than 50 patents worldwide for imaging technologies
  • Odyssey Imaging Systems are featured in more than 10,000 publications for detection and quantitation of protein expression

Quantitate the outcomes of your experiments on membranes, arrays, multi-well plates, and tissue sections, with our superior near-infrared fluorescence detection.

LI-COR also offers custom services through Science Exchange. Read a recent interview with Guru Singh (Director of Scientific Content, Science Exchange) and Jim Wiley (Director of Marketing, Biotechnology, LI-COR Biosciences) to find out more.

Ensuring Accurate Measurements of Biochemical Changes

Get the guidance you need: from setting up a new assay, protocol optimization, and reagent validation, to imaging, and data analysis. The LI-COR Custom Services team is adept at establishing protocols for protein quantitation, and offers comprehensive services for proteomics assays using the Odyssey imaging system platform.

Whether you are studying protein expression changes on membranes, arrays, or in cells and tissues, we provide complete Western blotting, array scanning, cell-based biochemical assay, near-infrared microscopy, and advanced cytometry services. You can count on us for guidance with upstream techniques such as nucleic acid cloning and amplification, protein expression, and protein purification.

Have you already set up your assays using chemiluminescence, colorimetric, or another detection method? Our team provides optimization and imaging support for a variety of detection chemistries.

ELISA Whole Organ Imaging
NIR in-cell

    Ask us about:

  • Quantitative Western Blotting
  • In-Cell Western™ and On-Cell Western assays
  • Antibody Validation
  • Imaging Probe Validation
  • Near-infrared Microscopy
  • Tissue Section Imaging
  • Cell-based Biochemical Assays
  • Array Scanning
  • Gel-shift Assays
  • Binding Assays
  • Specificity Studies
  • Immunocytochemistry
  • Enzyme Kinetics
  • Reagent Validation
  • Protocol Optimization

Schedule a consultation for your bioassay needs.

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Translational Services

LI-COR IRDye Infrared Dye fluorophores and the Pearl® Trilogy Small Animal Imaging Systems are enabling development of innovative diagnostic and therapeutic agents and optical imaging probes.

  • More than 300 publications cite the Pearl Small Animal Imaging Systems for in vivo imaging applications
  • Imaging agents conjugated to LI-COR IRDye infrared dye products are being investigated for human use in more than 16 active clinical trials (and counting…)

See how you can take your research from bench to clinic with our quantitative near-infrared fluorescence solutions.

Furthering Research Beyond the Bench

As you prepare to advance fluorophore-conjugated imaging and therapeutic agents to the clinic, place your confidence in the LI-COR Custom Services team. Through our experience in developing numerous IRDye-conjugated imaging agents, we have a thorough understanding of in vivo characterization, validation, and process optimization in small animals.

Bring the advantage of IRDye infrared dyes’ high signal-to-noise ratios, photo-stability, covalent conjugation, and clearance properties to visualize molecular targets and develop targeted therapies. We provide solutions and dual-mode imaging services on the Pearl Trilogy imager for efficient monitoring of optical agent biodistribution and localization in small animals.

IRDye fluorophore technology enables you to take imaging probes and agents systematically through in vitro, in vivo and ex vivo validation, then right into early phase clinical trials. Schedule a consultation to learn more about protocol optimization and validation best practices.

clinical trials

See a list of active clinical trials using IRDye conjugated probes and agents.

See All

    Ask us about:

  • Optical Imaging Probe Labeling
  • Nanoparticle Labeling
  • Imaging Probe Characterization
  • Biodistribution Studies
  • Clearance Studies
  • Uptake
  • Localization
  • Bone Density
  • Whole Organ Imaging
  • Ex Vivo Characterization
tumor imaging top tumor imaging lateral structural imaging

Contact us about your in vivo project needs.

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Manufacturing Services

LI-COR’s integrated chemical development and manufacturing services are helping bridge the gap between lab-scale and large-scale synthesis.

  • LI-COR has an on-site cGMP manufacturing facility
  • Our facilities are ISO 9001:2015 certified

Ask us about scale-up and transfer of your chemical synthesis protocols for research use, preclinical, and early-phase clinical projects.

Placing Large-Scale Synthesis Within Your Reach

Transfer of protocols and manufacturing of material for preclinical and clinical trial use is a high-risk venture. Let LI-COR Custom Services help you mitigate your risks with our scale-up and manufacturing services for IRDye infrared dyes, dye-conjugated probes, compounds, and active pharmaceutical ingredients (API) under current Good Manufacturing Practices (cGMP)*. For large and small-scale projects, you’ll get access to our state-of-the-art facilities, trained personnel, rigorous SOPs and quality standards to meet your goals.

Need custom synthesis for smaller-scale studies? Ask us about custom manufacturing services for research use only (RUO), and non-cGMP manufacturing for preclinical and toxicity studies. Our complete manufacturing solutions include analytical method development, manufacturing protocols, and stability studies under International Council for Harmonisation (ICH) guidelines.

We also provide custom reagent formulations and packaging, lyophilization services, and bulk quantities of our infrared dye and Western blotting reagents products.

* Products manufactured under cGMP are for investigational use only

    Ask us about:

  • Active Pharmaceutical Ingredients (API) Manufacturing
  • IRDye Technology for Clinical Applications
  • Pre-Clinical Manufacturing
  • Early Phase Clinical Manufacturing
  • New Reagent Formulations
  • Lyophilization Services
  • Small-Scale Manufacturing
  • Bulk Reagents
  • Custom Molecule Design

Learn more about our manufacturing services.

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Request a Free Project Evaluation

Talk directly to a scientist who will work closely with you to understand your needs and goals. You can customize any service to your particular research and discovery needs. A speedy turnaround time helps you meet deadlines with high-quality results from a trustworthy company.

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