IRDye® 800CW PEG Contrast Agent for Vascular, Lymphatic Imaging
LI-COR announces new near-infrared fluorescent agent for molecular imaging
October 1, 2009, Lincoln, NE: IRDye® 800CW PEG (polyethylene glycol) Contrast Agent is now available from LI-COR Biosciences. This reagent joins the company's growing line of products for near-infrared fluorescent molecular imaging. Tumor vasculature often displays enhanced permeability and retention, which allow contrast agents to "leak" into surrounding tissue and accumulate there. IRDye 800CW PEG exploits this property for cancer imaging. Intravenous injection of the agent highlights surface vasculature in appropriate mouse models, and retention in tumors is seen at later time points. It can also be used for lymph tracking after intradermal injection.
IRDye 800CW PEG can be imaged with the sensitive, high performance Pearl® Imager, or with the newly introduced Pearl Imager Impulse real-time imaging system. Both systems are optimized for near-infrared wavelengths, where light absorbance and autofluorescence of animal tissue are at their lowest. "With IRDye 800CW PEG, you can generate stunning images of the vasculature," says Jeff Harford, LI-COR product manager. "Tracking of lymph flow and lymph node identification can even be performed." The company also offers variety of other IRDye infrared dye reagents and molecular imaging agents.