February 26, 2009, Lincoln, NE: IRDye® 800CW RGD Optical Probe is fluorescent imaging agent designed for use in the study and/or monitoring of diseases related to the αvβ3 receptor over-expression. RGD (Arg-Gly-Asp) is a tripeptide sequence used to bind integrin receptors including αvβ3. Integrins are cell surface heterodimeric glycoproteins involved in cell-to-cell and cell-to-matrix interactions.
"Researchers studying integrin receptor expression in tumors will find RGD an excellent choice for in vivo imaging," says Jeff Harford, LI-COR senior marketing product manager. "We are continuing to expand our offerings of our IRDye Infrared Dyes for molecular imaging applications for use with our Pearl® Imager and other molecular imaging systems.
LI-COR offers an expanding line of IRDye Infrared Dye reagents and molecular imaging agents including: IRDye 800CW 2-DG, and IRDye 800CW EGF, a near-infrared labeled recombinant human epidermal growth factor for use in cancer studies. IRDye BoneTag™ is a calcium-chelating based probe for visualizing bone anatomy in small animals.
LI-COR Biosciences is a leading manufacturer of near-infrared imaging systems and LI-COR IRDye Infrared Dye reagents for quantitative Western Blotting, small animal imaging, and DNA fragment analysis. The company also offers accessories and reagents for other detection types. LI-COR pioneered the development of near-infrared fluorescence detection systems for DNA sequencing and today provides systems for drug discovery, protein research, small animal imaging, and undergraduate training.
LI-COR instruments for photosynthesis, carbon dioxide analysis and light measurement are recognized worldwide for standard-setting innovation in plant science research and environmental monitoring.
Founded in 1971, the privately held company is based in Lincoln, Nebraska, with subsidiaries in Germany and the United Kingdom. LI-COR systems are used in over 100 countries and are supported by a global network of distributors.