March 31, Lincoln, NE: LI-COR Biosciences is working with MitoSciences® to create specific assays used for disease and metabolic pathway research. MitoSciences recently released three In-Cell ELISA (ICE) Assays that monitor the stress-induced, species-variant, or tissue-specific changes or differences in the levels of mitochondrial and other metabolic targets. These assays, also known as In-Cell Western™ (ICW) Assays, offer a high-throughput method to determine protein levels in cultured cells that is both reproducible and quantitative.
"Researchers are able to obtain quantitative, highly sensitive data when using tools like near-infrared dye technology," says Jim Wiley, LI-COR senior strategic marketing manager. "Scientists benefit from both companies' technologies when they image their infrared ICE assays from MitoSciences on a LI-COR Odyssey Infrared Imaging System."
LI-COR's Odyssey® Infrared Imaging Systems set the standard for quantitative near-infrared fluorescence imaging. Additionally, LI-COR manufactures IRDye® fluorescent dye-labeled secondary antibodies that are incorporated into the MitoSciences ICE kits.
"MitoSciences has proven that LI-COR's technology provides an excellent platform for our antibodies, both in kits specific to particular research problems, as well as in broad screening approaches used for evaluating pathway-level changes due to diseases or drug effects," says Rod Capaldi, CSO of MitoSciences. "We are already seeing adoption of the kits for drug screening efforts, and are also undergoing collaborations with leading drug developers to demonstrate the technology's potential as a broad screening approach."
MitoSciences is the leading developer and manufacturer of monoclonal antibodies and immunoassays for use in understanding mitochondrial function and metabolism. MitoSciences' products are used by pharmaceutical companies, clinical laboratories, and basic researchers to unlock the role of metabolic enzymes in disease, drug therapy, and drug toxicology. MitoSciences' products also support the rapidly growing fields of systems biology and personalized medicine.