April 14, 2011, Lincoln, NE: As of April 2011, more than 3500 articles citing data from LI-COR's Odyssey Infrared Imaging System have been published. These publications cover a wide range of applications, including quantitative Western blots that follow changes in protein levels or modification of signaling pathway proteins, and imaging of whole tissue sections to confirm the pathology of molecular probes.
Some other cited applications include: the use of the In-Cell Western™ Assay to confirm the IC50 for a lead compound; Electrophoretic Mobility Shift Assays (EMSA) to assess interactions with transcription factors; reverse phase arrays to follow protein modifications in patient samples; in vivo imaging of tumors; and a protein trafficking assay.
"It is very exciting to see this list grow, with over 890 publications citing Odyssey data in the past 12 months," says Harry Osterman, PhD, LI-COR market innovation manager. "The diversity in the research is incredible and covers almost every research area, especially cancer research, cell biology, and neuroscience."
The Odyssey Infrared Imaging System uses near-infrared (NIR) fluorescence to produce data with high sensitivity over a wide linear dynamic range. It has become the standard for quantitative Western blot analysis. The Odyssey offers two-color detection and quantification simultaneously on the same membrane to increase the accuracy of quantification and comparison.