FieldBrite Xi Ensures Imaging Uniformity and High Sensitivity.
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  • Dynamic Range

  • Sensitivity

  • Even Illumination

FieldBrite Xi2 technology is the heart of the Pearl® Trilogy Imaging System. FieldBrite Xi2 is specifically optimized for small animal imaging. This attention to detail ensures you have the highest quality data possible.

FieldBrite Xi2:

  • Ensures the entire imaging area has uniform illumination so you can accurately monitor even the smallest changes
  • Uses infrared lasers to obtain the best signal-to-noise ratios possible and enables the detection of targets deep within the animal
  • Has an industry-leading 6 logs of dynamic range, so you never get saturated signal, which allows you to image all mice under the same optical conditions

Uniform Illumination

Reproducibility is critical for your research. And because many of your studies will be performed longitudinally, changes seen must reflect the biological changes of your experiment, not the limitations of your optical system.

FieldBrite Xi2 gives uniform illumination across the entire imaging area for this exceptional reproducibility (CV <3%). The laser illumination is stable throughout the course of your study - meaning any changes you see are based upon true biological phenomena.

A mouse organ (brain) was imaged 8x in variable locations using FieldBrite Xi2 technology. Move the slider to see the organ in each location. Note the CV is <3% across the entire field of view.

  • uniform illumination position 1

    Location 1

  • uniform illumination position 1

    Location 2

  • uniform illumination position 1

    Location 3

  • uniform illumination position 1

    Location 4

  • uniform illumination position 1

    Location 5

  • uniform illumination position 1

    Location 6

  • uniform illumination position 1

    Location 7

  • uniform illumination position 1

    Location 8

  1. Excitation Light Quality
  2. Excitation Light Leakage
  3. Signal-to-Noise Ratio

White Light

Very Poor
ex/em filters
Increased
Very Low

LED

Poor
ex/em filters
Increased
Low

NIR Laser

Excellent
FieldBrite Xi2
Low
High

Exceptional Sensitivity

Animal tissue strongly absorbs visible light, which prevents the light from reaching deeper targets. In addition, animal tissue has high autofluorescence when imaged in visible wavelengths (</=650 nm) which leads to poor Signal/Noise ratios and poor limits of detection.

Your solution is to image in the near-infrared (NIR)imaging window (680 nm – 820 nm). FieldBrite Xi2 optics ensure deep penetration of the tissue and also ensure the very best S/N ratios for the very best sensitivity.

FieldBrite Xi2 technology ensures the Pearl® Trilogy is sensitive enough to detect the small or deep tumors in your animal that are not yet palpable, both subcutaneous and orthotopic. Less probe is needed, making your experiments more cost effective.

Wide Dynamic Range

Dynamic range is critical in small animal imaging, because signal will vary by multiple logs between animals and/or across a longitudinal study with many animals. The 6-log dynamic range of FieldBrite Xi2 technology ensures the capture of pure data containing no saturation, allowing you to use the same camera settings for every image you acquire. Thanks to FieldBrite Xi2, you are now able to accurately and reliably compare and quantify changes across your entire study.

  • Pearl® Trilogy
  • Other Imagers
  • Example data from pearl Small Animal Imaging System, 1 Example data from other imager, 1
  • Example data from pearl Small Animal Imaging System, 2 Example data from other imager, 2
  • Example data from pearl Small Animal Imaging System, 3 Example data from other imager, 3
  • Example data from pearl Small Animal Imaging System, 4 Example data from other imager, 4
  • Example data from pearl Small Animal Imaging System, 5 Example data from other imager, 5

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