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Click Chemistry Overview

LI-COR offers a portfolio of Click Chemistry reagents for copper-catalyzed and copper-free methods, allowing the flexibility to choose the correct reagent for a diverse array of applications. Click here for a webinar outlining the uses of this technology.

Product Ordering Information

Order online or contact your local sales office.

Order online or contact your local sales office.

Order online or contact your local sales office.

To order, please contact your local distributor

Biomolecule labeling continues to be a cornerstone feature of many in vitro and in vivo biological experiments. Click Chemistry has recently emerged as a convenient, versatile, and reliable method for labeling a wide variety of molecules for applications ranging from biomarker isolation to assay development. Click Chemistry utilizes pairs of reagents that exclusively react with each other and are effectively inert to naturally occurring functional groups such as amines.

Features of Click Chemistry reagents:

  • Versatile alternative to affinity-based detection
  • Chemoselective, easy-to-perform, high yielding reactions
  • Offer flexibility with a choice for copper-catalyzed and
    copper-free reactions

Click Chemistry reactions can be categorized into two separate groups, copper-catalyzed or copper-free. Copper-catalyzed Click Chemistry is used for initiating reactions between azides and alkynes. Although they initiate and accelerate Click Reactions, copper catalysts are cytotoxic and inappropriate for use in living systems. To address this limitation, copper-free methods have been developed to allow Click Chemistry with live cells and whole organisms.

Click Chemistry Reactions Workflow

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