IRDye® 700DX Infrared Dye
The phthalocyanine dye IRDye 700DX has robust properties that make it suitable for optical imaging when conjugated to antibodies, receptor-binding ligands, small molecules, and more. It is considerably less sensitive to photobleaching than many other organic fluorochromes, and has excellent water solubility and salt tolerance. IRDye 700DX is available as an NHS ester and in labeling kits. Other forms are available through LI-COR Custom Services.
Features of IRDye 700DX:
- NHS ester reactive group for labeling primary and secondary amino groups
- Potential as a molecular-targeted cancer therapy, or photoimmunotherapy (PIT)1
- Excellent photostability, water solubility, and salt tolerance2
- Alternative to Quantum Dots
- M. Mitsunaga, M. Ogawa, N. Kosaka, L.T. Rosenblum, P.L. Choyke, H. Kobayashi, Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules. Nature Medicine17, 1685-1691, 2011.
- X. Peng, D.R. Draney, W.M. Volcheck, G.R. Bashford, D.T. Lamb, D.L. Grone, Y.Zhang, C.M. Johnson, Phthalocyanine dye as an extremely photostable and highly fluorescent near-infrared labeling reagent. Proceedings of SPIE 6097, 2006.
Aura Biosciences Closes $21M Series B Financing
Prepares to enter clinical trials for the treatment of rare ocular cancers
“…Aura’s lead product incorporates a viral nanoparticle conjugated with a potent cell-killing laser-activated molecule (IRDye 700DX, LI-COR Biosciences)… "Learn More
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