EGF Optical Probe Overview -
Why Target EGFR?
Product Ordering Information
IRDye® 800CW EGF Optical Probe is a BrightSite™ near-infrared (NIR) fluorescently-labeled recombinant human epidermal growth factor (EGF). Epidermal growth factor receptor (EGFR) is one of a family of receptor tyrosine kinases found on the surface of epithelial cells, to which EGF binds. Many types of cancer cells have abnormally high EGFR levels on the cell surface (Table 1). In vivo assays of EGF binding have proven effective in monitoring specific solid tumor models that exhibit overexpression of EGFR. EGF conjugated to the LI-COR NIR fluorophore, IRDye 800CW provides a versatile probes that can be used for in vitro and in vivo assays, as well as whole organ and tissue section analysis.
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|Tumor Type||% of Tumors Over-Expressing EGFR|
|Head and Neck||80-100|
Table 1. Frequency of elevated EGFR expression in different types of epithelial tumors1.
Figure 1. Intravenous administration of IRDye 680RD EGF (2 nmol) binds to the A431 tumor located on the right hip. Image captured 24 h post injection on the Pearl® Impulse Imaging System.