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EGF Optical Probe Overview -
Why Target EGFR?

Product Ordering Information

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Order online or contact your local sales office.

Order online or contact your local sales office.

To order, please contact your local distributor

IRDye® 800CW EGF Optical Probe is a BrightSite™ near-infrared (NIR) fluorescently-labeled recombinant human epidermal growth factor (EGF). Epidermal growth factor receptor (EGFR) is one of a family of receptor tyrosine kinases found on the surface of epithelial cells, to which EGF binds. Many types of cancer cells have abnormally high EGFR levels on the cell surface (Table 1). In vivo assays of EGF binding have proven effective in monitoring specific solid tumor models that exhibit overexpression of EGFR. EGF conjugated to the LI-COR NIR fluorophore, IRDye 800CW provides a versatile probes that can be used for in vitro and in vivo assays, as well as whole organ and tissue section analysis.

Frost & Sullivan Award

LI-COR is honored to have received this prestigious award from Frost & Sullivan. More about this reward.

Tumor Type % of Tumors Over-Expressing EGFR
Head and Neck 80-100
Renal Cell 50-90
Non-small-cell Lung 40-80
Glioma 40-50
Ovarian 35-70
Bladder 31-48
Pancreatic 30-50
Colon 25-77
Breast 14-91

Table 1. Frequency of elevated EGFR expression in different types of epithelial tumors1.

NHS Ester labeling cartoon

Figure 1. Intravenous administration of IRDye 680RD EGF (2 nmol) binds to the A431 tumor located on the right hip. Image captured 24 h post injection on the Pearl® Impulse Imaging System.

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