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Innovative Answers to Biomedical Questions
Whether you are monitoring the molecular basis of disease, or developing efficient drug delivery systems, targeted therapies and surgical contrast agents, quantitative near-infrared detection will help you find solutions to your complex research questions.
Explore Molecular Imaging Probe Development with LI-COR Near-Infrared Technology
Validate your dye-conjugated probes and agents in vitro, in vivo, and ex vivo with Odyssey® CLx and Pearl® Small Animal Imaging Systems, or schedule a consultation for your bioassay imaging needs with our biologists.
Get custom synthesis of your dye-conjugated probes and agents on a larger scale, and manufacturing (cGMP, non-cGMP) for clinical development with Custom Services.
Shape your targeting molecules into functionalized imaging probes and agents. Start with reporter dyes that get you sensitive and consistent detection for in vitro and in vivo use. If clinical translation is on your horizon, evaluate dyes with potential for human use.
Innovative Probe Design Solutions:
Get One Step Ahead of the Game
Take your imaging probes and agents from bench to clinic with a versatile reporter dye technology.
IRDye infrared dye fluorophores provide exceptional sensitivity and high signal-to-noise ratios for detection and quantitation. That’s because the IRDye advantage lies in near-infrared detection, where light absorption by and autofluorescence from cellular and tissue components is low. So, imaging agents labeled with these fluorophores allow biochemical activity measurements of in vitro and in vivo assays with high-sensitivity.
Image in the NIR imaging window for optimal sensitivity. Hemoglobin (Hb) and other tissue components strongly absorb visible light. In the NIR region, tissue absorbance is dramatically reduced, allowing light to easily pass through the tissue. Above 820 nm, light absorbance by water begins to increase.
Discover Your Options
LI-COR can help you out with instrumentation, software, protocols, dyes, and custom services through the entire probe development process.
“Among the fluorophores that we've used, the LI-COR dye, IRDye® 800CW seems to provide the ability to detect the tumors while maintaining suitable pharmacokinetics for use in vivo. It has worked quite well with our preclinical models.”
Assess your molecular probe’s biological performance in vitro, in vivo, and ex vivo. Maximize your chances of success with a detection technology that will get you quantitative and consistent data.
Screen for specificity and binding affinity with in vitro cell-based assays, then move your ‘hits’ to animal studies with confidence
Evaluate the big picture pharmacology with biodistribution and clearance studies in vivo, then get one step deeper
Measure uptake and localization in tissues and organs ex vivo for a complete workup
Image A showing On-Cell Western and Image C showing tissue sections acquired using Odyssey Imaging System. Image B showing tumor specificity in vivo was captured using Pearl Small Animal Imaging System.
Robust Bioassay Imaging Solutions:
Use one powerful detection technology for all your bioassays.
Equipped with laser-based NIR detection, the versatile Odyssey CLx Imaging System platform allows accurate quantitation of minute biochemical responses in a variety of assay formats. That means you can expedite the screening process for target specificity and binding affinity using higher throughput cell-based assays like In-Cell Western™ and On-Cell Western.
Engineered with single-camera optics and uniform illumination, the Pearl Trilogy provides an optimal imaging setup for small animal studies. The same laser-based NIR detection makes animal tissue virtually transparent, which aids greatly in tracking the biodistribution and clearance of probes and agents in vivo.
With its 21 µm scanning resolution, the Odyssey CLx Imaging System lets you screen for probe uptake, localization, and biodistribution in tissue sections and organs excised from treated animals. This facilitates macroscopic analysis without the need for an additional near-infrared microscope.
“Data from the Odyssey and Pearl Systems completely complement each other, which makes it easier to transition from cells to animals and back. We get more out of one animal compared to traditional methods.”
Image of IRDye 800CW conjugated probe localization (green) with stained nuclei (blue) captured using an Olympus epifluorescent microscope.
Get ready for clinical development of your imaging probes and agents. Team up with a service provider that understands your protocol development and manufacturing needs, and helps minimize risk.
Integrated Probe Manufacturing Solutions:
Your Compounds Made to Order
Take the leap towards clinical development of your research with confidence.
LI-COR Custom Services provides integrated expertise in the development, scale-up and manufacturing of IRDye infrared dyes, dye-conjugated probes, and imaging agents. Rely on us for efficient transfer of protocols to larger scale synthesis. We also provide custom manufacturing services of your compounds, agents, and probes under current Good Manufacturing Practices (cGMP) guidelines for early phase clinical trials, and non-cGMP manufacturing for preclinical and toxicity studies.