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    Innovative Answers to
    Biomedical Questions

    Whether you are monitoring the molecular basis of disease, or developing efficient drug delivery systems, targeted therapies and surgical contrast agents, quantitative near-infrared detection will help you find solutions to your complex research questions.

    Explore Molecular Imaging Probe Development with LI-COR Near-Infrared Technology

    Probe Design

    Convert your targeting molecules into reporter-labeled probes and agents with IRDye® infrared dye fluorophores, or ask us about our services for synthesis and bioconjugation.

    Probe Validation

    Validate your dye-conjugated probes and agents in vitro, in vivo, and ex vivo with Odyssey® CLx and Pearl® Small Animal Imaging Systems, or schedule a consultation for your bioassay imaging needs with our biologists.

    Probe Manufacturing

    Get custom synthesis of your dye-conjugated probes and agents on a larger scale, and manufacturing (cGMP, non-cGMP) for clinical development with Custom Services.

    Design

    Shape your targeting molecules into functionalized imaging probes and agents. Start with reporter dyes that get you sensitive and consistent detection for in vitro and in vivo use. If clinical translation is on your horizon, evaluate dyes with potential for human use.

    Innovative Probe Design Solutions:

    Get One Step Ahead of the Game

    Take your imaging probes and agents from bench to clinic with a versatile reporter dye technology.

    IRDye infrared dye fluorophores provide exceptional sensitivity and high signal-to-noise ratios for detection and quantitation. That’s because the IRDye advantage lies in near-infrared detection, where light absorption by and autofluorescence from cellular and tissue components is low. So, imaging agents labeled with these fluorophores allow biochemical activity measurements of in vitro and in vivo assays with high-sensitivity.

    But that’s not all. IRDye 800CW and 700DX fluorophores have found applications in preclinical and clinical use. Probes and agents conjugated to these dyes are currently being investigated for clinical use in 16 Phase I and Phase II trials.

    Image in the NIR imaging window for optimal sensitivity. Hemoglobin (Hb) and other tissue components strongly absorb visible light. In the NIR region, tissue absorbance is dramatically reduced, allowing light to easily pass through the tissue. Above 820 nm, light absorbance by water begins to increase.

    Discover Your Options

    Whether you need help labeling your unique targeting molecules, or would like specific dyes synthesized to your needs, you’ve got options.

    The LI-COR Custom Services team specializes in synthesis and bioconjugation of near-infrared dyes. We also provide services for purification, analytical characterization, and stability studies under ICH guidelines, for dye-conjugated imaging probes and agents.

    Get in Touch

    “Among the fluorophores that we've used, the LI-COR dye, IRDye® 800CW seems to provide the ability to detect the tumors while maintaining suitable pharmacokinetics for use in vivo. It has worked quite well with our preclinical models.”

    Dr. Martin G. Pomper, Johns Hopkins Medical School

    Validate

    Assess your molecular probe’s biological performance in vitro, in vivo, and ex vivo. Maximize your chances of success with a detection technology that will get you quantitative and consistent data.

    • Screen for specificity and binding affinity with in vitro cell-based assays, then move your ‘hits’ to animal studies with confidence
    • Evaluate the big picture pharmacology with biodistribution and clearance studies in vivo, then get one step deeper
    • Measure uptake and localization in tissues and organs ex vivo for a complete workup

    Image A showing On-Cell Western and Image C showing tissue sections acquired using Odyssey Imaging System. Image B showing tumor specificity in vivo was captured using Pearl Small Animal Imaging System.

    Robust Bioassay Imaging Solutions:

    Improve Productivity

    Use one powerful detection technology for all your bioassays.

    The Odyssey CLx Infrared Imaging System and the Pearl Trilogy Small Animal Imaging System provide an ideal near-infrared detection platform combination for complete analysis of your probe’s performance in vitro, in vivo, and ex vivo.

    Equipped with laser-based NIR detection, the versatile Odyssey CLx Imaging System platform allows accurate quantitation of minute biochemical responses in a variety of assay formats. That means you can expedite the screening process for target specificity and binding affinity using higher throughput cell-based assays like In-Cell Western™ and On-Cell Western.

    Engineered with single-camera optics and uniform illumination, the Pearl Trilogy provides an optimal imaging setup for small animal studies. The same laser-based NIR detection makes animal tissue virtually transparent, which aids greatly in tracking the biodistribution and clearance of probes and agents in vivo.

    With its 21 µm scanning resolution, the Odyssey CLx Imaging System lets you screen for probe uptake, localization, and biodistribution in tissue sections and organs excised from treated animals. This facilitates macroscopic analysis without the need for an additional near-infrared microscope.

    “Data from the Odyssey and Pearl Systems completely complement each other, which makes it easier to transition from cells to animals and back. We get more out of one animal compared to traditional methods.”

    Jelena Janjic, Duquesne University

    Complete Your Story with Accurate Data

    Your data is the foundation of your research discoveries. Get organized with Image Studio™ Software for acquiring, analyzing, quantitating, and archiving data images from LI-COR instruments.

    Configured with a user-friendly ribbon-based interface, Image Studio lets you analyze and quantitate validation data from micro-well plates, tissue sections, organs, and animals.

    Explore Some More

    Whether you want to microscopically analyze uptake and biodistribution or design a custom biochemical assay to characterize your probe, you’ve got guidance.

    The LI-COR Custom Services team provides consultation, assay development, optimization, imaging, and microscopy services for in vitro, in vivo and ex vivo validation projects.

    Get in Touch

    Image of IRDye 800CW conjugated probe localization (green) with stained nuclei (blue) captured using an Olympus epifluorescent microscope.

    Manufacture

    Get ready for clinical development of your imaging probes and agents. Team up with a service provider that understands your protocol development and manufacturing needs, and helps minimize risk.

    Integrated Probe Manufacturing Solutions:

    Your Compounds Made to Order

    Take the leap towards clinical development of your research with confidence.

    LI-COR Custom Services provides integrated expertise in the development, scale-up and manufacturing of IRDye infrared dyes, dye-conjugated probes, and imaging agents. Rely on us for efficient transfer of protocols to larger scale synthesis. We also provide custom manufacturing services of your compounds, agents, and probes under current Good Manufacturing Practices (cGMP) guidelines for early phase clinical trials, and non-cGMP manufacturing for preclinical and toxicity studies.

    Get in Touch
    • diagram illustrates the unparralelled sealing of the LI-6800 Portable Photosynthesis System
    • diagram showing maximized control on the LI-6800 Portable Photosynthesis System
    • diagram showing real-time guidance of the LI-6800 Portable Photosynthesis System

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