Clinical Trials

At LI-COR, we are dedicated to advancing the use of near-infrared detection and empowering you to extend the frontiers of biomedicine. Imaging probes and agents conjugated to IRDye® Infrared Dyes have propelled more than 20 Phase I and Phase II clinical trials worldwide.

  • IRDye 800CW
  • IRDye 800BK
human silhouette Brain Cancer

4
Head and Neck Cancer

3
Esophageal Cancer

2

 Breast Cancer

2
Lung Cancer

1
Pancreatic Cancer

2
Kidney Cancer

1

 Colorectal Cancer

2
Ureter Delineation*

2

 Endometriosis

1

Applications

Our products and services are enabling researchers to develop innovative approaches in cancer therapy, imaging diagnostics, and image-guided surgery.

Let your research take you to the next breakthrough.

Optoacoustic imaging

Optoacoustic imaging, also known as photoacoustic imaging or multispectral optoacoustic tomography (MSOT), is an optical imaging modality that employs near-infrared light illumination for ultrasound detection. Near-infrared fluorophore IRDye 800CW and QC-1 (quencher) undergoes optoacoustic effect following exposure to an MSOT imager and allows ultrasound detection from tissue.

imaged mice
Evaluating renal function in mouse models using multispectral optoacoustic tomography (MSOT). Control and Adriamycin-treated mice (to induce nephropathy) were administered IRDye 800CW for evaluating dye clearance and kidney function by MSOT imaging. Adapted from figures 3A-3E in Scarfe et al.

Biodistribution

Pre-clinical biodistribution labeling therapeutic agents and theranostics with near-infrared dyes like IRDye 800CW enables assessment of biological distribution, uptake, localization, and specificity of the targeting molecules. For FRET applications and in vivo biochemical studies, dual labeling of the targeting molecules with a fluorophore and a quencher (like QC-1) greatly assists in imaging.

imaged mice
Measuring biochemical activity of ATX (autotaxin) in tumor bearing mice in vivo. An AR-2 probe comprising of IRDye 800CW and QC-1 fluorophores was administered to tumor-bearing mice without (vehicle) and with ATX inhibitor (PF-8380). Upon cleavage by ATX, near-infrared fluorescence signal from probe components allowed in vivo biochemical characterization of ATX activity. Adapted from figures 6A–6C in Madan et al.
See more biodistribution/PKPD studies using IRDye Infrared Dye products

Image-guided surgery

Targeting molecules conjugated to near-infrared dyes such as IRDye 800CW can aid surgeons by enhancing visualization during procedures. Fluorophores can also be used as imaging agents to improve contrast. Optical imaging can improve surgical outcomes in neurosurgery, angiography, lymph node mapping, and tumor resection.

imaged mice
Intraoperative visualization of small cancerous lesions. Mice injected intraperitoneally with cancer cells expressing the surface protein EpCAM, were administered IRDye-labeled EpCAM-specific antibody. Detection and imaging of cancer lesions was performed using the Pearl Imager. Adapted from figures 5a-5b in van Driel et al.
See other publications on image guided surgery using IRDye Infrared Dye products

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References
  1. Nagaya T, Nakamura Y, Sato K, et al. Near infrared photoimmunotherapy with avelumab, an anti-programmed death-ligand 1 (PD-L1) antibody. Oncotarget. 2017;8(5):8807-8817. doi:10.18632/oncotarget.12410.
  2. Scarfe L, Rak-Raszewska A, Geraci S, et al. Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy. Scientific Reports. 2015;5:13601. doi:10.1038/srep13601.
  3. Madan D, Ferguson CG, Lee WY, Prestwich GD, Testa CA. Non-Invasive Imaging of Tumors by Monitoring Autotaxin Activity Using an Enzyme-Activated Near-Infrared Fluorogenic Substrate. Bogyo M, ed. PLoS ONE. 2013;8(11):e79065. doi:10.1371/journal.pone.0079065.
  4. Van Driel PBAA, Boonstra MC, Prevoo HAJM, et al. EpCAM as multi-tumour target for near-infrared fluorescence guided surgery. BMC Cancer. 2016;16:884. doi:10.1186/s12885-016-2932-7.
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