IRDye® 680RD BoneTag Optical Probe

Study Bone Growth and Change with IRDye 680RD BoneTag.

IRDye 680RD BoneTag Optical Probe is a calcium-chelating compound conjugated to IRDye 680RD near-infrared dye. Using IRDye NIR dyes extends fluorescence signal detection to the near-infrared fluorescent region of the spectrum without affecting the compound’s ability to function as a marker of the mineralization process. NIR fluorescence detection improves depth of penetration due to low tissue autofluorescence, translating to low background interference.

Calcium-chelating compounds have been used effectively for the detection of bone mineralization, growth, and morphological changes, including tetracycline derivatives, xylenol orange, alizarin, calcein, and fluorescein. NIR-labeled pamidronate has also been successfully used for detection of arterial calcification in non-invasive optical imaging1.

Learn about other LI-COR optical probes.

Applications

Absorbance and Emission Spectra

Data Example

Image of IRDye tumor specific agent and IRDye BoneTag optical probe. The pseudocolor represents the 800 nm channel with red representing the highest level of signal. The white arrow points to the tumor while the orange arrow points to stomach signal. The grey scale image represents the IRDye BoneTag incorporated in skeletal features (700 nm image).

References

  1. Zaheer A et al. (2001) In vivo near-infrared fluorescence imaging of osteoblastic activity. Nat Biotechnol, 19. 1148-54.
  2. Kovar, J. L., Xu, X., Draney, D., Cupp, A., Simpson, M. A., & Michael Olive, D. (2011). Anal Biochem, 416(2), 167–173. doi: 10.1016/j.ab.2011.05.011.

Selected P/N: 926-09374

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